論文・書籍PUBLICATIONS

2004年以前

  • Yamada Y, Oike Y, Ogawa H, Ito Y, Fujisawa H, Suda T, and Takakura N. Neuropilin-1 on hematopoietic cells as a source of vascular development. Blood 101:1801-1809, 2003.
  • Nakajima M, Yuasa S, Ueno M, Takakura N, Koseki H, Shirasawa T. Abnormal blood vessel development in mice lacking presenilin-1. Mech Dev 120: 657-667, 2003.
  • Li Z, Takakura N, Oike Y, Imanaka T, Araki K, Suda T, Kaname T, Abe K, and Yamamura, K. Defective smooth muscle development in qkI deficient mice. Dev Growth Differ 45:449-461, 2003.
  • Takakura N. Hematopoietic stem cells and angiogenesis. Cardiomyopathies and Heart Failure. Kluwer Academic Publishers. 469-480, 2003.
  • Sano H, Ueda Y, Takakura N, Takemura G, Doi T, Kataoka H, Murayama T, Xu Y, Sudo T, Nishikawa S, Nishikawa S, Fujiwara H, Kita T, Yokode M. Blockade of platelet-derived growth factor receptor-beta pathway induces apoptosis of vascular endothelial cells and disrupts glomerular capillary formation in neonatal mice. Am J Pathol 161: 135-143, 2002.
  • Ogawa T, Takayama K, Takakura N, Kitano S and Ueno H. Anti-tumor angiogenesis therapy using soluble receptors: enhanced inhibition of tumor growth when soluble fibroblast growth factor receptor-1 is used with soluble vascular endothelial growth factor receptor. Cancer Gene Ther 9:633-640, 2002.
  • Suenobu S, Takakura N, Inada T, Yamada Y, Yuasa H, Zhang XQ, Sakano S, Oike Y and Suda T. A role of EphB4 receptor and its ligand, ephrin-B2, in erythropoiesis. Biochem Biophys Res Commun 293: 1124-1131, 2002.
  • Yuasa H, Takakura N, Shimomura T, Suenobu S, Yamada T, Nagayama H, Oike Y, Suda T. Analysis of human TIE2 function on hematopoietic stem cells in umbilical cord blood. Biochem Biophys Res Commun 298: 731-737, 2002.
  • Koga K, Todaka T, Morioka M, Hamada J, Kai Y, Yano S, Okamura A, Takakura N, Suda T, and Ushio Y. Expression of angiopoietin-2 in human glioma cells and its role for angiogenesis. Cancer Res 61:6248-6254, 2001.
  • Zhang XQ, Takakura N, Oike Y, Inada T, Gale NW, Yancopoulos GD, and Suda T. Stromal cells expressing ephrin-B2 promote the growth and sprouting of ephrin-B2(+) endothelial cells. Blood98:1028-1037, 2001.
  • Sano H, Sudo T, Yokode M, Murayama T, Kataoka H, Takakura N, Nishikawa S, Nishikawa SI, and Kita T. Functional blockade of platelet-derived growth factor receptor-beta but not of receptor-alpha prevents vascular smooth muscle cell accumulation in fibrous cap lesions in apolipoprotein E-deficient mice. Circulation 103:2955-2960, 2001.
  • Yamada Y, Takakura N, Yasue H, Ogawa H, Fujisawa H, and Suda T. Exogenous clustered neuropilin-1 enhances vasculogenesis and angiogenesis. Blood 97: 1671-1678, 2001.
  • Sano H, Yokode M, Takakura N, Takemura G, Doi T, Kataoka H, Sudo T, Nishikawa S, Fujiwara H, Nishikawa SI, and Kita T. Study on PDGF receptor beta pathway in glomerular formation in neonate mice. Ann N Y Acad Sci 947: 947:303-305, 2001.
  • Suda T, and Takakura N. Role of hematopoietic stem cells in angiogenesis. Int J Hematol 74: :266-271, 2001.
  • Takakura N, Watanabe T, Suenobu S, Yamada Y, Noda T, Ito Y, Satake M, and Suda T. A role for hematopoietic stem cells in promoting angiogenesis. Cell 102, 2, 199-209, 2000.
  • Hamada K, Oike Y, Takakura N, Ito Y, Jussila L, Dumont DJ, Alitalo K, and Suda T. VEGF-C signaling pathways through VEGFR-2 and VEGFR-3 in vasculo-angiogenesis and Hematopoiesis. Blood 96, 12, 3793-3800, 2000.
  • Suda T, Takakura N, and Oike Y. Hematopoiesis and angiogenesis. Int J Hematol 71, 2, 99-107, 2000.
  • Oike Y, Takakura N, Hata A, Kaname T, Akizuki M, Yamaguchi Y, Yasue H, Araki K, Yamamura K, and Suda T. Mice homozygous for a truncated form of CREB-binding protein exhibit defects in hematopoiesis and vasculo-angiogenesis.Blood 93, 2771-2779, 1999.
  • Hamaguchi I, Huang X-L, Takakura N, Tada J, Yamaguchi Y, Kodama H, Suda T. In vitro hematopoietic and endothelial cell development from cells expressing TEK receptor in murine aorta-gonad- mesonephros region. Blood 93:1549-1556,1999.
  • Takakura N, Huang XL, Naruse T, Hamaguchi I, Dumont DJ, Yancopoulos GD, Suda T. Critical role of the TIE2 endothelial cell receptor in the development of definitive hematopoiesis. Immunity 9 : 677-86, 1998.
  • Huang XL, Takakura N, and Suda T. In vitro effects of angiopoietins and VEGF on hematopoietic and endothelial cells. Biochem Biophys Res Commun 264:133-138, 1999.
  • Sato A, Iwama A, Takakura N, Nishio H, Yancopoulos GD, and Suda T. Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells. Int Immunol 10 : 1217-27, 1998.
  • Yoshida H, Takakura N, Hirashima M, Kataoka H, Tsuchida K, Nishikawa S, Nishikawa S. Hematopoietic tissues, as a playground of receptor tyrosine kinases of the PDGF-receptor family. Dev Comp Immunol 22: 321-32, 1998.
  • Nakamura YS, Hakeda Y, Takakura N, Kameda T, Hamaguchi I, Miyamoto T, Kakudo S, Nakano T, Kumegawa M, Suda T. Tyro 3 receptor tyrosine kinase and its ligand, Gas6, stimulate the function of osteoclasts. Stem Cells 16 : 229-38, 1998.
  • Ogura Y, Takakura N, Yoshida H, Nishikawa SI. Essential role of platelet-derived growth factor receptor alpha in the development of the intraplacental yolk sac/sinus of Duval in mouse placenta. Biol Reprod 58 : 65-72, 1998.
  • Kataoka H, Takakura N, Nishikawa S, Tsuchida K, Kodama H, Kunisada T, Risau W, Kita T, and Nishikawa SI. Expressions of PDGF receptor alpha, c-Kit and Flk1 genes clustering in mouse chromosome 5 define distinct subsets of nascent mesodermal cells. Dev Growth Differ 39 : 729-40, 1997.
  • Takakura N, Ogawa M, Kodama H, Nishikawa S, Nishikawa S. Self-renewal of hematopoietic progenitor cells under defined condition. Leukemia 11 : 460, 1997.
  • Kanatsu M, Takakura N, Kataoka H, Tsuchida K, Nishikawa S, Nishikawa S. In vitro analysis of potency restriction during epiblast differentiation. Leukemia 11: 457-459, 1997.
  • Takakura N, Yoshida H, Ogura Y, Kataoka H, Nishikawa S, Nishikawa S. PDGFR alpha expression during mouse embryogenesis: immunolocalization analyzed by whole-mount immunohistostaining using the monoclonal anti-mouse PDGFR alpha antibody APA5. J Histochem Cytochem 45: 883-93, 1997.
  • Yoshida H, Takakura N, Kataoka H, Kunisada T, Okamura H, and Nishikawa SI. Stepwise requirement of c-kit tyrosine kinase in mouse ovarian follicle development. Dev Biol 184 : 122-37, 1997.
  • Takakura N, Kodama H, Nishikawa S, and Nishikawa S. Preferential proliferation of murine colony-forming units in culture in a chemically defined condition with a macrophage colony-stimulating factor-negative stromal cell clone. J Exp Med 184 : 2301-9, 1996.
  • Fruttiger M, Calver AR, Kruger WH, Mudhar HS, Michalovich D, Takakura N, Nishikawa S, Richardson WD. PDGF mediates a neuron-astrocyte interaction in the developing retina. Neuron 17: 1117-31, 1996.
  • Takakura N, Yoshida H, Kunisada T, Nishikawa S, Nishikawa SI. Involvement of platelet-derived growth factor receptor-a in hair canal formation. J Invest Dermatol 107: 770-7, 1996.
  • Nagasawa T, Hirota S, Tachibana K, Takakura N, Nishikawa S, Kitamura Y, Yoshida N, Kikutani H, and Kishimoto T. Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nature382 : 635-8, 1996.
  • Nishikawa S, Nakasato M, Takakura N, Ogawa M, Kodama H, Nishikawa S. Stromal cell-dependent bone marrow culture with a nearly protein-free defined medium. Immunol Lett 40:163-169, 1994.
  • Oka K, Ohno T, Kita K, Yamaguchi M, Takakura N, Nishii K, Miwa H, and Shirakawa S. PRAD1 gene over-expression in mantle-cell lymphoma but not in other low-grade B-cell lymphomas, including extranodal lymphoma. Br J Haematol 86: 786-791, 1994.
  • Miwa H, Kita K, Nishii K, Morita N, Takakura N, Ohishi K, Mahmud N, Kageyama S, Fukumoto M, and Shirakawa S. Expression of MDR1 gene in acute leukemia cells: association with CD7+ acute myeloblastic leukemia/acute lymphoblastic leukemia. Blood 82: 3445-3451, 1993.
  • Kita K, Nishii K, Ohishi K, Morita N, Takakura N, Kawakami K, Miwa H, and Shirakawa S. Frequent gene expression of granulocyte colony-stimulating factor (G-CSF) receptor in CD7+ surface CD3- acute lymphoblastic leukaemia. Leukemia 7: 1184-1190, 1993.
  • Miwa H, Kita K, Saya H, Otsuji A, Masuya M, Nishii K, Morita N, Takakura N, Ohishi K, Nasu K, et al. Structural alterations of the p53 gene in human leukemias. Leuk Res 16: 1105-1112, 1992.
  • Kita K, Nakase K, Miwa H, Masuya M, Nishii K, Morita N, Takakura N, Otsuji A, Shirakawa S, Ueda T, et al. Phenotypical characteristics of acute myelocytic leukemia associated with the t(8;21)(q22;q22) chromosomal abnormality: frequent expression of immature B-cell antigen CD19 together with stem cell antigen CD34. Blood 80: 470-477, 1992.
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